Genetics of Parkinson’s disease in Brazil: a systematic review of monogenic forms

ABSTRACT Background: Increasing numbers of mutations causing monogenic forms Parkinson's disease (PD) have been described, mostly among patients in Europe and North America. Since genetic architecture varies between different populations, studying the specific profile Brazilian is essential for improving counseling selecting clinical trials. Objective: We conducted a systematic review to identify studies on set background future PD Brazil. Methods: searched MEDLINE, EMBASE Web Science from inception December 2019 using terms "Parkinson's disease", "genetics" "Brazil". Two independent reviewers extracted data. For genes LRRK2 PRKN, estimated prevalence was calculated each study, meta-analysis performed. Results: A total 32 were included, comprising 94 with causative mutation, identified 2,872 screened (3.2%). PRKN 48 out 576 (8.3%). 40 1,556 (2.5%), p.G2019S most common mutation (2.2%). Conclusions: autosomal recessive cause PD, dominant form. observed that there lack robust epidemiological genetics Brazil and, especially, diversity Brazil’s population had not considered.